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Annapureddy N Injuries requiring medical treatment are considered to be "reportable incidents," and must be reported to the NJDOE within five working days of the occurrence. Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) - Full Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. http://oml.eular.org/glossary (31 January. CareerBuilder TIP. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Five centres in Great Britain and the Republic of Ireland have collaborated to produce a computerized index of clinical disease activity in systemic lupus erythematosus, based on the principle of the physician's intention to treat. The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus. , Urowitz MB Gandhi N All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. , Jnsen A A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). , Gladman DD All rights reserved. One study showed a significant ability of the PGA in distinguishing between patients (P<0.0001) and observers (P<0.0001), but not between visits [79]. The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Results: , Oon S Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Instrument selection using the OMERACT filter 2.1: the OMERACT methodology, The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes, Health measurement scales: a practical guide to their development and use, A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus, Efficacy and safety of methotrexate in articular and cutaneous manifestations of systemic lupus erythematosus, Performance of SLEDAI-2K to detect a clinically meaningful change in SLE disease activity: a 36-month prospective cohort study of 334 patients, Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort, Comparison of the systemic lupus erythematosus activity questionnaire and the systemic lupus erythematosus disease activity index in a black Barbadian population, A pilot study to determine the optimal timing of the Physician Global Assessment (PGA) in patients with systemic lupus erythematosus, Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments, Derivation and validation of the SLE Disease Activity Score (SLE-DAS): a new SLE continuous measure with high sensitivity for changes in disease activity, Clinical SLEDAI-2K zero may be a pragmatic outcome measure in SLE studies, Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE, Validation of SIMPLE index for lupus disease activity, Performance characteristics of different anti-double-stranded DNA antibody assays in the monitoring of systemic lupus erythematosus, Psychometric properties of MDHAQ/RAPID3 in patients with systemic lupus erythematosus, Therapeutic adherence in patients with systemic lupus erythematosus: a cross-sectional study, Sensitivity analyses of four systemic lupus erythematosus disease activity indices in predicting the treatment changes in consecutive visits: a longitudinal study, Comparison of the lupus foundation of America-rapid evaluation of activity in lupus to more complex disease activity instruments as evaluated by clinical investigators or real-world clinicians, Lupus low disease activity state is associated with a decrease in damage progression in Caucasian patients with SLE, but overlaps with remission, Impact of disease activity on health-related quality of life in systemic lupus erythematosusa cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS), Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study, Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus, Cross-cultural validation of Lupus Impact Tracker in five European clinical practice settings, Failure of a systemic lupus erythematosus response index developed from clinical trial data: lessons examined and learned, Belimumab for the treatment of recalcitrant cutaneous lupus, Progression of noncalcified and calcified coronary plaque by CT angiography in SLE, Impact of heart rate variability, a marker for cardiac health, on lupus disease activity, The lupus impact tracker is responsive to changes in clinical activity measured by the systemic lupus erythematosus responder index, Validation of the Lupus Impact Tracker in an Australian patient cohort, Axl, ferritin, IGFBP2 and TNFR2 as biomarkers in systemic lupus erythematosus, Lupus anticoagulant, disease activity and low complement in the first trimester are predictive of pregnancy loss, Lupus Impact Tracker is responsive to physician and patient assessed changes in systemic lupus erythematosus, Predictors of pregnancy outcomes in patients with lupus: a cohort study, Clinical, laboratory and health-related quality of life correlates of Systemic Lupus Erythematosus Responder Index response: a post hoc analysis of the phase 3 belimumab trials, Validation of the LupusPRO in Chinese patients from Hong Kong with systemic lupus erythematosus, The Swiss Systemic lupus erythematosus Cohort Study (SSCS)cross-sectional analysis of clinical characteristics and treatments across different medical disciplines in Switzerland, How should lupus flares be measured? If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. , Rairie JE Despite the need for new treatments in CLE . Patient and Physician Global Assessments of Disease Status in Systemic The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). Published by Oxford University Press on behalf of the British Society for Rheumatology. , McGuire JL. , McGwin G The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA Objective: It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . et al. et al. Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. , Friebus-Kardash J The correlation with the SLEDAI was determined in 12 studies (Fig. J Clin Med. , Francis S Data regarding divergent validity are lacking for the PGA. The PGA was developed on a 0 to 3 scale as part of the Lupus Activity Index. AU - Kasitanon, Nuntana. , Kandane-Rathnayake RK [35], the PGA correlated, although moderately, with the need for treatment change (r=0.46, P<0.01). et al. For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . , Jolly M. Mok CC Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. , Magder LS The quantification of reliability is expressed by a correlation coefficient. Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. Touma Z Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv Merrill JT In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. , Shinada S The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. , Fang H , Zonana-Nacach A Physician Global Assessment International Standardisation COnsensus in No study has evaluated the feasibility of the PGA in SLE to date. The index assesses separately eight organ-based systems. watch for seizures after the procedure. Changes in the PGA correlated with changes of other disease activity indices (SLEDAI, SLAM, LAI, patient global assessment), laboratory exams (ESR), patient-reported outcomes (Lupus Impact Tracker) [23, 50, 58, 77, 78, 81, 83] and response to treatment [4]. , Anderson N , Hochberg M. Touma Z AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . , Floris A The following search strategy was used through MEDLINE via PubMed: (((lupus erythematosus, systemic[MeSH Terms] OR (lupus[TIAB] AND erythematosus[TIAB] AND systemic[TIAB]) OR systemic lupus erythematosus[TIAB] OR (systemic[TIAB] AND lupus[TIAB] AND erythematosus[TIAB]))) OR SLE[TIAB]) AND (physician global assessment[TIAB] OR PGA[TIAB]). , Chakravarty E FOIA Some may be a consequence of therapy and others may be . . Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. There is no cure for lupus, but medical . lupus erythematosus; systemic outcome assessment; qualitative research; healthcare; We read with great interest the recent paper by Aranow et al 1 about the impact of laboratory results on scoring of the Physician Global Assessment (PGA) of disease activity in systemic lupus erythematosus (SLE). A multi-item Physician Global Assessment scale to assess psoriasis The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. It estimates how similar a given patients scores were at the two visits. Mayara Torres Silva de Oliveira, MD, MBA on LinkedIn: #medicinanuclear Gyri N , Trendelenburg M The aim of this systematic literature review is to describe and analyse the . , Nelson S The official NJDOE Incident Reporting Form, as well as a guide to completing , Smiley A. Askanase AD Ruiz-Irastorza G [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Federal government websites often end in .gov or .mil. , Schur PH. , Devilliers H An international panel of 79 SLE experts participated in a three-round Delphi consensus . et al. It operates in Albuquerque, and New Mexico. , Wallace DJ , Tugwell P Retrieved papers were selected with no limitation on the year of publication, language or patients age. , Costenbader K Supervise the development of junior medical affairs staff . 2019ACREULAR . disease activity). Barr SG The site is secure. Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. , Criscione-Schreiber LG , Guzmn RM , Lerman RH Cloud, mobility, security, and more. , Morabito LM Vashisht P Associations between physicians' global assessment of disease activity Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. Quimby KR BICLA is a validated composite global measure of SLE disease activity including SLEDAI-2K, CLASI-A, OCS dosage reduction, and patient-reported outcomes. Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. , Socher SA IgM) on attainment PhGA. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 SLE231 Hydrology and Water Resources Management: Excursion or Virtual Tour BICLA responders had fewer lupus-related serious . Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. Once two investigators (E.C., M.P.) Barr et al. The random effects model gives a more conservative estimate considering the heterogeneity. , Ibaez D They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. PGA is an important tool for assessing disease activity, response to treatment (it is a component . [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. , Shea BJ , Cappellazzo G Rheumatology (Oxford). , Giannakou I [PDF] Use of Physician Global Assessment in systemic lupus Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . , Koutsoviti S HHS Vulnerability Disclosure, Help RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) In the second column, the definitions were reported according to the VAS used in the study. , Taghavi-Zadeh S . Thus the development of a comprehensive index for assessing disease activity still represents one of the most important challenges in SLE [7]. Montreal, Canada Area. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA.