COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19associated hospitalizations in 99 counties across 14 states. COVID-19associated hospitalizations are those occurring among residents of a predefined surveillance catchment area who have a positive real-time reverse transcriptionpolymerase chain reaction (RT-PCR) or rapid antigen detection test result for SARS-CoV-2 during hospitalization or the 14 days preceding admission. State data show the average age for COVID deaths was about 80 in late 2020, but dropped in spring 2021 to as low as 69 after most older adults received their first COVID vaccines. In supplemental analyses by trimester of vaccination, receipt of the second dose during the second and third trimesters reduced the risk of infants testing SARS-CoV-2 positive during the Delta dominant period by 91% (95% CI: 63, 98) and 85% (95% CI: 50, 96), respectively, during the first 2 months of life, by 59% (95% CI: 21, 79) and 67% (95% CI: 37, 83) during the first 4 months of life and by 64% (95% CI:31, 81) and 53% (95% CI: 24, 71) during the first 6 months of life. COVID-19 vaccination coverage among pregnant women during pregnancyEight Integrated Health Care Organizations, United States, December 14, 2020-May 8, 2021. TN, NMF, WH, and SA wrote the software. 20, 15225 (2016). The second study, led by Office for National Statistics researchers in Wales, involved death rates and risk factors in adults in England who had received an mRNA booster at least 14 days before Dec 31, 2021. Accessed March 10, 2022. J. Med. According to the Ontario Science Table's online dashboard, the hospital occupancy rate for the unvaccinated was 611 per million unvaccinated people in the province's population as of Jan. 7,. Perm. Unvaccinated Children Hospitalized at Twice the Rate During Omicron Delta period: July 1, 2021December 18, 2021, reflects the time when Delta was the predominant circulating variant; Omicron period: December 19, 2021January 31, 2022, reflects the time when Omicron was the predominant circulating variant. SARS-CoV-2 infections can result in COVID-19associated hospitalizations, even among vaccinated persons. Vaccine 31, 21652168 (2013). * Adults who completed a primary vaccination series were defined as those who had received the second dose of a 2-dose primary vaccination series or a single dose of a 1-dose product 14 days before a positive SARS-CoV-2 test associated with their hospitalization but received no booster dose. The University of Minnesota is an equal opportunity educator and employer, Office of the Vice President for Research | Contact U of M | Privacy Policy, Mary Van Beusekom | News Writer | CIDRAP News, Two recent papers claim there are no differences between surgical masks and respirators for preventing the spread of respiratory diseases like COVID-19 and flu, but the articles. Mountain lions, a bobcat, red foxes, black bears, and skunks represent the latest avian flu cases in mammals. Urban Health 83, 10411062 (2006). The finding that maternal vaccination was less effective at protecting infants during the Omicron dominant period is also consistent with previous studies which have reported decreased effectiveness of mRNA COVID-19 vaccines during Omicron among children and adults14,20. Effectiveness of Covid-19 vaccines in ambulatory and inpatient care settings. While Omicron caused a big spike in COVID-19 cases, vaccinated people continued to be less likely to be hospitalized than the unvaccinated. SARS-CoV-2 delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. T.R. Hobbs, C. V. et al. COVID is still killing people every day. But its main victims have Additional COVID-NET methods for determining vaccination status have been described previously. During the Omicron-predominant period, weekly COVID-19associated hospitalization rates (hospitalizations per 100,000 adults) peaked at 38.4, compared with 15.5 during Delta predominance. CAS Infants were followed from birth until the first positive SARS-CoV-2 test by PCR at age 2, 4, or 6 months, with censoring due to death, health plan disenrollment, or end of follow-up (May 31, 2022). https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765 (2022). No other exclusion criteria were applied. PubMed COVID-19 hospitalizations look different in the Omicron wave, and We did not have genotyping data to confirm the variant that infected infants who tested positive and instead relied on state data regarding circulating strain predominance in the Northern California region. PubMed The researchers used the QCovid risk model to estimate hazard ratios (HRs) for clinical risk factors. Garg S, Patel K, Pham H, et al. Slider with three articles shown per slide. Introduction: A rapid increase in COVID-19 cases due to the spread of the Delta and Omicron variants in vaccinated populations has raised concerns about the hospitalization risk associated with, and the effectiveness of, COVID-19 vaccines. PubMed As of January 26, 2022, 39.6% of Black persons received a primary vaccine series; of those, 43.9% of adults received a booster dose once eligible. CAS 226, 236 e1236.e14 (2022). The average age of decedents was 83.3 years. From this cohort, the study excluded the following infants born to (1) mothers who were not between ages 16 and 50 years at pregnancy onset; (2) mothers who did not have a primary KPNC facility assignment; (3) mothers who were not continuous KPNC members from December 15, 2020 until delivery; (4) mothers who had a positive nasal/throat swab for SARS-CoV-2 by polymerase chain reaction (PCR) prior to pregnancy onset; (5) mothers who had a positive SARS-CoV-2 antibody test documented by KPNC prior to the onset of pregnancy; (6) mothers who received one or more doses of COVID-19 vaccine prior to pregnancy onset. COVID-19 vaccines have demonstrated both high efficacy in clinical trials and high real-world effectiveness, especially against the original and Delta variant of the virus6,7,8,9,10. Wkly Rep. 71, 352358 (2022). All rights Reserved. Initial hospital data from England and Denmark also suggest Omicron cases are less severe. The vaccines have proved highly safe and effective at reducing the risk of severe illness, hospitalization and death. However, protection estimates greater than 90% might be too high if individuals with a previous infection were more likely than those without one to come forward for a test for reasons other than suspicion of COVID-19. Vaccine effectiveness of cell-culture relative to egg-based inactivated influenza vaccine during the 2017-18 influenza season. South Africa omicron crisis: Cases, hospitalizations and - CNBC Pediatrics. While this proportion might not be representative of the proportion of vaccinated pregnant women within KPNC because of our exclusion criteria, more efforts are needed to promote COVID-19 vaccines for pregnant persons because vaccination provides protection to mothers and their infants until they are old enough to receive their own COVID-19 vaccines. We did not assess whether vaccines received before pregnancy or immediately after pregnancy were associated with a reduced risk of testing positive for SARS-CoV-2 in infants. PubMedGoogle Scholar. B., Lewis. Ousseny Zerbo. The objective of this study was to further evaluate the effectiveness of at least two doses of mRNA COVID-19 vaccination during pregnancy for preventing SARS-CoV-2 infection in infants during the first 2, 4, and 6 months of life during the Delta and Omicron variant periods. Our findings that receipt of at least two doses of COVID-19 vaccine during pregnancy was effective at protecting infants during the Delta period are similar to those reported in a recent Norwegian study showing that mRNA COVID-19 vaccination during pregnancy was associated with a 71% decreased risk of testing positive for SARS-CoV-2 in infants during their first 4 months of life during the Delta period17. KPNC has a comprehensive electronic health record system (Kaiser Permanente HealthConnect, a customized EPIC system), that captures detailed information on all medical services, including immunization, membership enrollment including place of residence, demographics, and pregnancy-related care from pregnancy onset to delivery, and beyond. It is possible that our exclusion criteria may have resulted in a final sample that may not be reflective of all KPNC infants. Suggested citation for this article: Taylor CA, Whitaker M, Anglin O, et al. During the Delta dominant period, the crude incidences of testing positive for SARS-CoV-2 during the first 2, 4, and 6 months of life were lower among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy (0.75, 1.43, and 1.56 infants per 100 person-years [PY], respectively) than those whose mothers were not vaccinated during pregnancy (5.47, 5.10, and 4.78 infants per 100 PYs, respectively). J., Fireman. In the meantime, to ensure continued support, we are displaying the site without styles If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. 387, 109119 (2022). provided as a service to MMWR readers and do not constitute or imply With the emergence of the SARS-CoV-2 Omicron variant in late 2021, Canadian public health case/contact testing was scaled back due to high infection rates with milder symptoms in a highly vaccinated population. Female sex was a protective factor (HR, 0.52), while residence in a nursing home or low-income area was a risk factor. About half of long-COVID patients who were on sick leave at 4 months were still on sick leave at 2 years. Hospitalization Risk from Omicron 'Around a Third of Delta' - WebMD Foo, D., Sarna, M., Pereira, G., Moore, H. C. & Regan, A. K. Longitudinal, population-based cohort study of prenatal influenza vaccination and influenza infection in childhood. 1CDC COVID-19 Emergency Response Team; 2General Dynamics Information Technology, Atlanta, Georgia; 3California Emerging Infections Program, Oakland, California; 4Career Epidemiology Field Officer Program, CDC; 5Colorado Department of Public Health & Environment; 6Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut; 7Emory University School of Medicine, Atlanta, Georgia; 8Georgia Emerging Infections Program, Georgia Department of Public Health; 9Atlanta Veterans Affairs Medical Center, Atlanta, Georgia; 10Iowa Department of Public Health; 11Michigan Department of Health and Human Services; 12Minnesota Department of Health; 13New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico; 14New York State Department of Health; 15University of Rochester School of Medicine and Dentistry, Rochester, New York; 16Ohio Department of Health; 17Public Health Division, Oregon Health Authority; 18Vanderbilt University Medical Center, Nashville, Tennessee; 19Utah Department of Health. The exposure of interest was mRNA COVID-19 vaccination status during pregnancy in the electronic health record. Cookies used to make website functionality more relevant to you. Iowa does not provide data on vaccination status. How likely is COVID-19 hospitalization for vaccinated Americans? - USAFacts Informed consent was waived because this was a data-only study with no direct contact with participants. The results were published yesterday in JAMA Network Open. For mothers of infants in the cohort, we extracted from the electronic health record data: age at pregnancy onset, self-reported race/ethnicity (Asian, Black, Hispanic, Pacific Islander, Multiracial, Native American, Other, White), the primary KPNC facility at which the woman received most of their health care, insurance payor (dichotomized as Medicare/Medicaid/other subsidized insurance and Other), neighborhood deprivation index [NDI]35 categorized into quartiles with higher values representing greater deprivation), pre-pregnancy body mass index (BMI=kg/m2; underweight <18.5, normal 18.524.9, overweight 25.029.9, obese 30.0), pre-pregnancy diabetes status, pre-pregnancy hypertension, and parity (0, 1, 2, 3, 4). Over the entire study period, the crude rate of hospitalization with a SARS-CoV-2 positive test was lower during the first 6 months of life among infants whose mothers received at least two doses . **** ICU admission and IMV are not mutually exclusive categories, and patients could have received both. 384, 22732282 (2021). PubMed Central J. Med. Chi-square tests were used to compare differences between the Delta- and Omicron-predominant periods; p-values <0.05 were considered statistically significant. 2022 The Authors. and statistical significance was assessed at two-sided p0.05. Vaccines: The CDC recommends that everyone age 5 and older get an updated covid booster shot. The study was conducted among a cohort of infants born between December 15, 2020, and May 31, 2022. Acosta AM, Garg S, Pham H, et al. Starting the week ending December 4, 2021, Maryland data are not included in weekly rate calculations but are included in previous weeks. Data about boosters was only available for those over 50. Among the infants in the cohort, 19,418 (64.06%) of the mothers were unvaccinated during pregnancy, 1138 (3.75%) of the mothers received one dose of an mRNA COVID-19 vaccine and 9755 (32.18%) received 2 doses during pregnancy (Table1). CAS It's not clear which variant might have been associated with these hospitalizations. Office of the Vice President for Research. All authors (O.Z., B.F., N.P.K., T.R., M.G., E.L., P.R., K.G., S.O., and E.L.) critically reviewed the manuscript and decided to proceed with publication. https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1 In conclusion, in this population-based cohort study, we found that infants born to mothers who received at least two doses of an mRNA COVID-19 vaccine during pregnancy were at lower risk of testing positive for SARS-CoV-2 and were at lower risk of hospitalization during the first 6 months of life compared with infants whose mothers were unvaccinated during pregnancy.
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